“Unlocking phenotypic plasticity” is one of the capabilities described in “Hallmarks of Cancer” which denotes how cancer cells and the cells within the tumor microenvironments (TME) could change the identify to achieve advantages during progression. Epithelial-mesenchymal transition (EMT) is such a mechanism that has been shown to contribute to cellular plasticity. Epithelial-Mesenchymal Plasticity (EMP) is a concept to describe the ability of cells to adopt mixed EM features and to interconvert between intermediate EM phenotypic states arrayed along the phenotypic spectrum. It is essential to gaze into the EMP Spectrum from the multiomics perspective to understand the interconnectedness of regulatory mechanisms. This talk will elucidate how multiomics technologies from bulk, single cell, to spatially resolved profiling could decipher the EMP Spectrum from the 3D genome architecture, chromatin landscape, and transcriptomic neighbourhoods in cancer cells.